Null vote.

I've gone to using the 3d on line and 2d off line in combination.

#d is very good at twaeking postioning and error checking (as well as the initial rough work if not well familiar with the model), but the added tools [​ie, masks, layer modes, layer groups, infinite undo, etc] in 2D make it superior for much of the work.


EDIT: If one reads the question as either 'the most skins have been produced from which' or 'which do the largest number of people use', I would think the answers are 2D (although I expect 3D to surpass it) for the first because of the legacy effect DGTC notes, but 3D for the second both beacause of the ease with which new persons can produce something at least passible and because teh 3D tools are available online without download.

I use both, 2D when I need to change colors and check for errors but 3D for designing.

I'd imagine 2D skinning is largely more used than 3D, as it's been around for years and is very simple to use if you have the right tools.